Down Syndrome

and Dementia

Down Syndrome and Alzheimer's Disease

The association of Down syndrome and Alzheimer's disease has been noted for many years and Down syndrome is considered a major risk factor for the disease. Numerous organizations have produced briefs on this association and guides for caregivers and others interested in knowing more. A brief list of the national organizations and links to their sites is provided to the right.

Alzheimer's Association (US)

Centers for Disease Control

Down Syndrome Resource Foundation

National Down Syndrome Society

National Institute on Aging

Down Syndrome & Dementia Resources

The NTG has been involved in efforts to better advocate for supports to adults with Down syndrome and and their families and provide information on dementia assessment and supports. These are some publications and documents that may be of use.

Regression (Down Syndrome)

Book chapter

Down Syndrome

and Dementia

Down Syndrome and Alzheimer's Disease

Down Syndrome & Dementia Resources

Regression (Down Syndrome)

Mental Wellness in Adults with Down Syndrome: A Guide to Emotional and Behavioral Strengths and Challenges (2nd Ed.)

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer’s disease

The National Task Group on Intellectual Disabilities and Dementia Practices consensus recommendations for the evaluation and management of dementia in adults with intellectual disabilities

Dementia in Mentally Disabled Hard to Identify

Importance in Overall Health in Adults with Intellectual Disability and Dementia

CMS decision on Aduhelm: An Explainer by LuMind IDSC

COVID-19 and Down Syndrome Resources Guide

NTG's FAQ on aducanumab and Down syndrome

Aducanumab: Panacea or Risk for Adults with Down Syndrome

Aducanumab and Persons with Down Syndrome: What Do We Do Now? (Statement)

ISTAART Down Syndrome PIA Report on Research in 2020

Evaluation of the National Task Group-Early Detection Screen for Dementia: Sensitivity to 'Mild Cognitive Impairment' in Adults with Down Syndrome

Clinical and biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study

Further understanding the connection between Alzheimer’s disease and Down syndrome

Down syndrome disintegrative disorder: A clinical regression syndrome of increasing importance

Regression and loss of skills in adolescents and adults with Down syndrome

New definition of unexplained regression in Down syndrome proposed

Unexplained regression in Down syndrome: 35 cases from an international Down syndrome database

Catatonia in Down syndrome: Systematic approach to diagnosis, treatment and outcome assessment based on a case series of seven patients

Down Syndrome & Dementia News